Honeycomb reactor: a promising device for streamlining aerobic oxidation under continuous-flow conditions

• Masahiro Hosoya,
• Yusuke Saito and
• Yousuke Horiuchi

Beilstein J. Org. Chem. 2023, 19, 752–763, doi:10.3762/bjoc.19.55

• structure raised the mixing efficiency of a gas–liquid reaction system, and it effectively accelerated the aerobic oxidation of benzyl alcohols to benzaldehydes under continuous-flow conditions. This reactor is a promising device for streamlining aerobic oxidation with high process safety because it is a

• the reactor. As the gas–liquid reaction mixture passes through the honeycomb reactor, the porous material functions as a static mixer, maintaining high mixing efficiency throughout the aerobic oxidation process. We believe that this processing technology offers much potential for application as a flow

Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide

• Kyoko Mandai,
• Tetsuya Yamamoto,
• Hiroki Mandai and
• Aiichiro Nagaki

Beilstein J. Org. Chem. 2022, 18, 660–668, doi:10.3762/bjoc.18.67

• with good operational stability, evaluated by a constant high yield of cyclohexene oxide, to obtain the desired product with high productivity. Keywords: air; continuous flow; cyclohexene oxide; flow epoxidation; rapid gas–liquid reaction; Introduction From the past to the present, organic synthesis

• has contributed to the development of science and technology. With the rapid advances in the 21st century, increasing demand for organic synthesis has led to a strong need for faster and more sophisticated methods. The gas–liquid reaction is one of the organic synthetic methods of importance because

• gases are one of the promising reagents concerning environmental aspects. Demands for the use of gases for constructing various functional organic materials should be increased if a reliable and powerful technique for gas-liquid reaction is established. In a conventional batch process, a faster reaction

A method to determine the correct photocatalyst concentration for photooxidation reactions conducted in continuous flow reactors

• Clemens R. Horn and
• Sylvain Gremetz

Beilstein J. Org. Chem. 2020, 16, 871–879, doi:10.3762/bjoc.16.78

• little as possible” [8]. This phrase describes the approach used to scale up flow reactors to an industrial scale [9][10]. This is particularly true when it comes to biphasic reactions, like a gas/liquid reaction as is the case for photooxidations [11]. An interesting aspect of photooxidations is that

Assessing the possibilities of designing a unified multistep continuous flow synthesis platform

• Mrityunjay K. Sharma,
• Roopashri B. Acharya,
• Chinmay A. Shukla and
• Amol A. Kulkarni

Beilstein J. Org. Chem. 2018, 14, 1917–1936, doi:10.3762/bjoc.14.166

• separator enters into the tubular reactor TR3 at a temperature of 20–40 °C with a residence time of 4 hours. Into this reactor nitrogen gas was pumped through peristaltic pump P7 and formic acid using pump P8. In TR3 gas–liquid reaction takes place. Formation of the lactate salt: In step four, lactic acid

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

• Chinmay A. Shukla and
• Amol A. Kulkarni

Beilstein J. Org. Chem. 2017, 13, 960–987, doi:10.3762/bjoc.13.97

• . gas–liquid reaction (viz. amitriptyline synthesis [7]), gas–liquid–solid reactions ((±)-oxomaritidine synthesis [9]) and liquid–solid reactions (viz. (S)-rolipram synthesis [4]). The process was also selected on the basis of the heating technique used, viz induction heating (olanzapine synthesis [10

Camera-enabled techniques for organic synthesis

• Steven V. Ley,
• Richard J. Ingham,
• Matthew O’Brien and
• Duncan L. Browne

Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118

• argon, and from which the solution of products is injected into a second palladium-catalysed gas/liquid reaction. This represents a major step towards a universal and sustainable in-line separation and purification module to enable the direct connection of multiple stages in a flow-synthesis procedure

Triple-channel microreactor for biphasic gas–liquid reactions: Photosensitized oxygenations

• Ram Awatar Maurya,
• Chan Pil Park and
• Dong-Pyo Kim

Beilstein J. Org. Chem. 2011, 7, 1158–1163, doi:10.3762/bjoc.7.134

• oxygenations of α-terpinene, citronellol, and allyl alcohols. Keywords: gas–liquid reaction; microreactor; photosensitization; singlet oxygen; Introduction Microreactors have recently attracted much interest among the scientific community for performing laboratory operations on small scales [1][2][3][4][5][6

• -step synthesis [30][31], process safety [32][33][34], photo-reactions [35][36][37][38][39], gas-liquid reactions [40][41][42][43], etc. In a biphasic gas–liquid reaction, mass transfer from the gas phase to the liquid phase proceeds through the interfacial area. In traditional batch reactors, the

• biphasic gas–liquid reaction by enhancing the effective interfacial area [44][45]. In the dual-channel microreactor, in which the top and bottom channels were separated by a thin polydimethylsiloxane (PDMS) membrane, gas from the bottom channel diffused into the solution of the top channel. Thus, only one